Company Overview
About Amplitude Vascular Systems
Amplitude Vascular Systems (AVS) is a medical device company headquartered in Fremont, California, founded to develop next-generation intravascular lithotripsy (IVL) technology for treating calcified peripheral artery disease (PAD). The company''s flagship product, the Pulse IVL system, delivers high-frequency pulsatile pressure waves through a catheter-based device to fracture calcium deposits in arterial walls — restoring vessel compliance and improving blood flow in patients with calcified, obstructed arteries in the legs, below-the-knee vessels, and other peripheral vascular territories. Calcified PAD is a significant and growing clinical problem, particularly in diabetic patients and the aging population, where conventional balloon angioplasty and stenting are less effective due to hard, calcified lesion morphology.
Business Model & Competitive Advantage
AVS raised over $75M in total funding to support device development and clinical trials, competing in an IVL market pioneered by Shockwave Medical (acquired by Johnson & Johnson for $13.1B in 2024). While Shockwave focused on coronary and peripheral IVL with its S-IVL and C-IVL systems, AVS is developing a differentiated IVL approach targeting specific clinical niches in peripheral vascular intervention — including below-the-knee (BTK) territories that Shockwave''s current coronary-focused system does not address. The Pulse IVL system is designed to deliver controlled pressure waves with a distinct frequency and energy profile from Shockwave''s sonic pressure wave approach.
Competitive Landscape 2025–2026
AVS is in active clinical development stages, with ongoing feasibility and pivotal trials supporting a potential FDA clearance pathway for its Pulse IVL system. The company represents a next-generation challenger in the IVL market — entering a space that Shockwave''s acquisition by J&J has validated at massive scale, while pursuing differentiated device technology and peripheral vascular indications where clinical need remains high and competitive alternatives are limited.
Key Differentiators
Emerging Innovator
Amplitude Vascular Systems is an emerging player bringing innovative solutions to the Life Sciences & BioTech market.
Frequently Asked Questions
Estimated Visibility Trend (Beta)
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