Amplitude Vascular Systems vs Emulate
Side-by-side comparison of AI visibility scores, market position, and capabilities
Intravascular Lithotripsy & Calcified Artery Treatment Devices
Amplitude Vascular Systems (AVS) is a medical device company developing the Pulse IVL system — a high-frequency pulsatile pressure wave device for treating calcified peripheral artery disease; raised $75M+ total;
About
Amplitude Vascular Systems (AVS) is a medical device company headquartered in Fremont, California, founded to develop next-generation intravascular lithotripsy (IVL) technology for treating calcified peripheral artery disease (PAD). The company''s flagship product, the Pulse IVL system, delivers high-frequency pulsatile pressure waves through a catheter-based device to fracture calcium deposits in arterial walls — restoring vessel compliance and improving blood flow in patients with calcified, obstructed arteries in the legs, below-the-knee vessels, and other peripheral vascular territories. Calcified PAD is a significant and growing clinical problem, particularly in diabetic patients and the aging population, where conventional balloon angioplasty and stenting are less effective due to hard, calcified lesion morphology.
Pioneering organ-on-chip platform installed in 150+ labs including 17 of the top 25 biopharma companies; launched AVA™ high-throughput 96-chip system in 2025 and holds the only FDA ISTAND-accepted DILI Organ-Chip.
About
Emulate, Inc. is a Boston-based biotechnology company that designs, manufactures, and commercializes Organ-Chip technology — micro-engineered devices lined with living human cells that replicate the microstructure and function of human organs. Founded in 2013 as a spin-out from the Wyss Institute at Harvard University, Emulate's chips model the liver, intestine, lung, kidney, brain, and other organ systems with a fidelity that animal models and traditional cell culture cannot match. The technology was originally developed to reduce drug development attrition rates caused by poor translation from animal studies to human clinical outcomes.
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