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Positive 48-week Phase 2 BEHOLD data for UBX1325 in DME published in NEJM Evidence. Single-injection senolytic durability confirmed in diabetic macular edema.
Unity Biotechnology is the most clinically advanced senolytic drug company, with its UBX1325 program delivering long-lasting vision improvements in diabetic macular edema (DME) from a single intravitreal senolytic injection. The 48-week Phase 2 BEHOLD trial data published in NEJM Evidence (one of the highest-impact medical journals) confirmed durable efficacy — maintained vision improvement with a single injection over nearly a year — validating the senolytic hypothesis in human ocular disease.
Signed $2.1B Novo Nordisk collaboration (Feb 2026). Platform enables oral delivery of proteins and peptides (historically injection-only). MIT Langer lab spinout.
Vivtex is an MIT Langer Laboratory spinout that has developed a drug delivery platform enabling oral administration of biologics — proteins, peptides, and other large molecules — that have historically required injection because they are degraded by stomach acid and too large to absorb through the intestinal wall. In February 2026, Vivtex signed a $2.1 billion collaboration agreement with Novo Nordisk for the development of oral formulations of biologic drugs in obesity, diabetes, and metabolic disease.
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