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Sana Biotechnology develops engineered cell and gene therapies with fusogen delivery technology to treat serious diseases through in vivo and ex vivo approaches.
Sana Biotechnology is a publicly traded gene therapy company founded in 2018 by veterans of Juno Therapeutics and other leading cell therapy companies. The company is building technologies to repair or replace any gene in any cell, with a particular focus on its proprietary fusogen-based delivery platform that enables engineered cells to fuse with and deliver genetic material to specific target cells in the body. This approach could enable off-the-shelf cell therapies and in vivo gene editing without the need to harvest and engineer patient cells individually. Sana has programs targeting blood cancers, autoimmune diseases, and type 1 diabetes, exploring both in vivo gene delivery and ex vivo engineered cell therapies. The company went public through an IPO in 2021, raising substantial capital to advance its novel platform. Sana has formed research collaborations with academic institutions and pharmaceutical companies to advance specific programs. The company represents the cutting edge of cell and gene therapy with proprietary delivery technologies that could unlock new therapeutic approaches beyond what current viral vector and CRISPR systems enable.
Microbiotica raised $105M Series C in 2025 for its gut microbiome platform linking bacterial strains to disease, enabling live biotherapeutic products for cancer immunotherapy and IBD.
Microbiotica applies genomics and machine learning to map the gut microbiome's causal role in disease, then develops live biotherapeutic products (LBPs) targeting the specific bacterial strains responsible. The company's Reference Microbiome database — built from thousands of patient samples — is the world's most comprehensive catalog of gut bacteria linked to disease outcomes, providing a systematic foundation for microbiome drug discovery.
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