Evozyne vs Tempus
Side-by-side comparison of AI visibility scores, market position, and capabilities
Evozyne applies generative AI and evolutionary principles to design novel therapeutic proteins; raised $144M total including $81M Series B led by Fidelity and OrbiMed with NVIDIA NVentures participation; 54 employees; Chicago-based.
About
Evozyne is a Chicago-based biotechnology company founded in 2020 by Andrew Ferguson and Rama Ranganathan that uses generative AI to design novel, high-performance proteins for therapeutic and commercial applications. The company occupies a distinctive position at the frontier of AI-driven drug discovery: unlike companies that apply AI to screen existing molecule libraries or predict protein folding (like AlphaFold), Evozyne generates entirely new protein sequences from scratch using its proprietary understanding of evolutionary sequence-function relationships. These de novo proteins are designed with specific functional properties for therapeutic development or industrial applications.
Publicly traded AI precision medicine company (Nasdaq: TEM); $1.27B revenue in 2025 (+83% YoY); $14B+ market cap; genomic profiling, algorithmic diagnostics, and clinical trial matching across oncology, neurology, and cardiology.
About
Tempus AI is a technology company applying artificial intelligence to advance precision medicine across oncology, neurology, psychiatry, and cardiology. Founded in 2015 by Eric Lefkofsky (co-founder of Groupon) and headquartered in Chicago, Illinois, Tempus built the world's largest library of clinical and molecular data and applies AI to help physicians make more personalized, data-driven treatment decisions. The company's core offerings include genomic profiling (sequencing tumor DNA to identify mutations and actionable targets), algorithmic diagnostic tests (AI-driven companion diagnostics for cancer treatment selection), clinical trial matching (connecting eligible patients to appropriate studies), and data licensing to pharmaceutical and biotech partners for drug discovery and clinical development.
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