Profluent Bio vs Vial
Side-by-side comparison of AI visibility scores, market position, and capabilities
AI protein design company released OpenCRISPR-1, the first gene editor designed entirely by AI; raised $35M developing novel enzymes, antibodies, and gene-editing tools by exploring protein sequence space beyond what evolution has produced.
About
Profluent Bio is an AI protein design company founded in 2022 by former Meta AI researcher Ali Madani, raising $35M in seed and Series A funding. The company trains large generative models on biological sequence data to design novel proteins with specific structural and functional properties, analogous to how large language models generate text. Profluent made scientific history in 2024 by publishing OpenCRISPR-1, the first gene editor designed entirely by AI rather than adapted from natural organisms, which the company released open source for non-commercial research. The platform enables design of novel enzymes, antibodies, and gene-editing tools by exploring protein sequence space far beyond what evolution has produced. Profluent works with pharmaceutical and agricultural biotechnology companies that need custom protein tools for research and therapeutic development. The company represents a fundamental advance in moving protein engineering from directed evolution and rational design toward generative AI-driven discovery.
Vial is a tech-enabled CRO that converts dermatology and ophthalmology clinics into research sites, handling regulatory administration, equipment provisioning, and patient recruitment; raised $77M Series B in 2022;
About
Vial is a clinical research organization (CRO) founded in 2020 by Simon Burns and Jason Wang and headquartered in San Francisco, California. The company has built a technology-enabled model for running clinical trials that differs from traditional CROs by directly partnering with clinical practices — particularly in dermatology and ophthalmology — and converting them into research sites. Vial handles the full operational burden: regulatory and IRB submissions, site staff training, clinical equipment provisioning, electronic data capture (EDC) setup, and patient recruitment and scheduling. This allows clinics with no prior research experience to participate in trials, dramatically expanding the pool of available sites and accelerating patient enrollment timelines.
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