Alveus Therapeutics vs Nuvig Therapeutics
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Alveus Therapeutics raised $150M Series A in 2025 for inhaled mRNA therapeutics targeting pulmonary diseases including idiopathic pulmonary fibrosis and COPD, bringing mRNA technology directly to the lung.
About
Alveus Therapeutics is applying mRNA medicine to pulmonary diseases by developing inhaled mRNA formulations that deliver protein replacement or gene editing instructions directly to lung cells. Unlike systemic mRNA therapeutics that require IV infusion and liver targeting, Alveus's inhaled approach delivers mRNA locally to lung epithelial cells, enabling treatment of diseases like idiopathic pulmonary fibrosis (IPF), COPD, and cystic fibrosis with potentially lower doses and fewer systemic side effects.
Nuvig Therapeutics develops first-in-class Fc-fragment immunomodulators targeting endogenous regulatory pathways to treat autoimmune diseases without broad immune suppression.
About
Nuvig Therapeutics is a privately held biotechnology company developing next-generation immunomodulatory therapies for patients with chronic inflammatory and autoimmune diseases. Its lead candidate, NVG-2089, is a first-in-class recombinant Fc fragment engineered to bind type II Fc receptors and engage an endogenous regulatory mechanism that restores immune balance without the broad immunosuppression associated with existing treatments.
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