Presidio Medical logo

Presidio Medical

Challenger

Presidio Medical develops an ultra-low frequency (ULF) spinal cord stimulation platform for nociceptive lower back pain; raised $102M total including $72M Series C from Deerfield; 95% responder rate in trials.

Best for: Neuromodulation & Chronic Pain Devices
HealthcareNeuromodulation & Chronic Pain DevicesWebsiteUpdated May 2026

Company Overview

About Presidio Medical

Presidio Medical is a clinical-stage medical technology company developing a next-generation neuromodulation platform for treating chronic nociceptive lower back pain. Founded in 2017 and headquartered in South San Francisco, California, the company''s Ultra Low Frequency (ULF™) Neuromodulation System delivers precisely calibrated, ultra-low frequency electrical pulses through spinal cord stimulation (SCS) electrodes to inhibit neuronal pain responses localized to the lower back — without relying on paresthesia (the tingling sensation associated with older SCS devices).

Business Model & Competitive Advantage

Presidio Medical has raised $102 million in total funding, including a $72 million Series C led by Deerfield Management with participation from Invus Opportunities and Action Potential Venture Capital. The company received FDA IDE approval to conduct a pivotal US clinical trial of the ULF platform. Early clinical data is compelling: in a feasibility study, 95% of patients were responders (≥50% pain reduction) and 90% were profound responders (≥80% pain reduction). These outcomes compare favorably with existing SCS platforms.

Competitive Landscape 2025–2026

Presidio Medical competes in the spinal cord stimulation market against established players such as Medtronic, Boston Scientific, Abbott, and Nevro. Its differentiation lies in the ULF waveform, which the company believes targets nociceptive pain — the most common form of chronic back pain — more effectively than high-frequency or burst stimulation approaches. CEO Michael Onuscheck brings decades of experience in the medical device industry to lead the company toward pivotal trial completion and eventual FDA premarket approval.

Founded
2017
Headquarters
South San Francisco, California
Curated content • Fact-checked and verified

Key Differentiators

Strong Challenger

Presidio Medical is an established challenger with significant market presence and competitive offerings in Healthcare.

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