Cleancard

Emerging

US YC S23 at-home 30-minute cancer screening for prostate, bladder, and ovarian cancers; $846K Mayo Clinic/TQ Ventures/YC-backed with synthetic biology + computer vision from Oxford Rhodes Scholar founders competing with GRAIL for accessible early cancer detection.

Updated March 2026

Company Overview

About Cleancard

Cleancard is a United States-based at-home cancer screening company — backed by Y Combinator (S23) with $846,000 in total funding from Mayo Clinic Platform, TQ Ventures, Urban Innovation Fund, Y Combinator, and the Creative Destruction Lab — developing a 30-minute at-home diagnostic platform that combines synthetic biology, machine learning, and computer vision to detect multiple cancer biomarkers from a single patient sample for prostate, bladder, and ovarian cancers. Founded by Luca Springer and Thomas Carroll (both Rhodes Scholars from Oxford), Cleancard targets the massive unmet need for accessible, affordable cancer screening outside of clinical settings — the 30-minute result time and home-based format enabling screening at the frequency and convenience required for early cancer detection programs.

Business Model & Competitive Advantage

Cleancard's at-home cancer screening technology addresses the access and adherence barriers that reduce the effectiveness of existing cancer screening programs: prostate-specific antigen (PSA) testing, bladder cancer urine cytology, and ovarian cancer CA-125 testing are all clinic-based procedures that require scheduling appointments, traveling to labs, and waiting days for results — friction that causes eligible patients to skip routine screening or delay follow-up after abnormal results. Cleancard's platform uses synthetic biology-engineered biosensors (designed to detect specific cancer biomarker proteins or genetic signatures in urine or blood samples) combined with computer vision analysis of the test result pattern (reading the quantitative biomarker level from the test strip or cartridge format) to deliver clinical-grade sensitivity and specificity in a consumer-facing format. The multiplexable format (detecting multiple cancer biomarkers from a single sample) enables panel testing that improves early detection probability compared to single-marker testing — a key advance over current single-analyte home tests. Mayo Clinic Platform's investment provides the clinical validation infrastructure and healthcare system distribution relationships that consumer diagnostic companies require for clinical adoption.

Competitive Landscape 2025–2026

In 2025, Cleancard competes in the at-home diagnostics, cancer screening, and consumer health testing market with Galleri (Illumina/GRAIL multi-cancer early detection liquid biopsy, $1.9B raised), Exact Sciences (NASDAQ: EXAS, Cologuard colorectal cancer screening, $1B revenue), and EarlySign (AI-based early cancer detection, $21M raised) for consumer and healthcare system early cancer detection platform adoption. Mayo Clinic Platform's partnership (Mayo Clinic is one of the world's most trusted healthcare institutions) provides clinical validation credibility critical for consumer cancer diagnostic adoption where clinical trust is paramount. Rhodes Scholar founding team backgrounds reflect the academic research rigor that translates synthetic biology biosensor research into manufacturable consumer diagnostic products. The 2025 strategy focuses on achieving clinical validation data for the prostate and bladder cancer panels, pursuing FDA 510(k) clearance for at-home use authorization, and building the telehealth follow-up pathway for patients with positive screening results.

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Key Differentiators

Emerging Innovator

Cleancard is an emerging player bringing innovative solutions to the Healthcare market.

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