Company Overview
About Calyxo
Calyxo is a medical device company founded in 2017 and headquartered in Pleasanton, California, focused on improving outcomes in kidney stone treatment. The company's lead product is the CVAC System (Calyxo Vacuum-Assisted Catheter), an FDA-cleared ureteroscopy tool that uses suction to vacuum out kidney stone fragments during a single minimally invasive procedure. Traditional stone removal with a basket retrieval device requires multiple passes and often leaves residual fragments — a problem Calyxo's system addresses by continuously aspirating debris as the laser breaks up stones, achieving substantially higher stone-free rates in a single operating room session.
Business Model & Competitive Advantage
Calyxo raised an $80M Series C in 2023 led by Longitude Capital, with participation from New Enterprise Associates (NEA) and other investors, bringing its total funding to approximately $130M. The capital is being deployed to drive commercial adoption across urology centers and academic medical centers in the United States. The CVAC System is designed for compatibility with existing ureteroscopes and stone-treating lasers — allowing adoption without major capital equipment purchases — and its workflow fits within the standard ureteroscopy procedure time, which supports same-day surgical center settings.
Competitive Landscape 2025–2026
Kidney stones affect approximately 1 in 10 Americans, with over 600,000 emergency room visits per year and roughly 1.2 million ureteroscopy procedures performed annually in the US. The residual stone fragment problem is clinically significant: even small remaining fragments can lead to repeat procedures and ongoing patient morbidity. Calyxo's technology addresses this directly, positioning CVAC as a standard-of-care upgrade to the ureteroscopy procedure that can be adopted by urologists with minimal training.
Key Differentiators
Emerging Innovator
Calyxo is an emerging player bringing innovative solutions to the Healthcare market.
Frequently Asked Questions
Estimated Visibility Trend (Beta)
Simulated 8-week rolling score
Based on estimated brand signals. Historical tracking coming soon.
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