Avise Health

Avise Medical is a specialty diagnostics company founded in 2012 that develops laboratory tests specifically designed to help rheumatologists diagnose and monitor autoimmune diseases including lupus, rheumatoid arthritis, and related conditions. The company's flagship products include AVISE Lupus, a panel of blood biomarkers that increases diagnostic accuracy for systemic lupus erythematosus compared to traditional single-marker tests, and AVISE CTD for connective tissue disease diagnosis. Autoimmune diseases are notoriously difficult to diagnose because symptoms overlap with many other conditions and individual biomarkers have limited sensitivity and specificity. Avise addresses this through multi-biomarker panels that use machine learning to combine signals into diagnostic scores with better performance characteristics. The company works directly with rheumatology practices and provides specialized clinical interpretation support for complex cases. Avise raised over $100M and expanded its diagnostic portfolio to cover monitoring of disease activity and treatment response in addition to initial diagnosis. The company represents the application of advanced biomarker discovery and machine learning to specialty diagnostics in rheumatology.