# Gameto

**Source:** https://geo.sig.ai/brands/gameto  
**Vertical:** BioTech  
**Subcategory:** Reproductive Medicine  
**Tier:** Emerging  
**Website:** gametogen.com  
**Last Updated:** 2026-04-14

## Summary

Gameto raised $70M Series B in 2024 for its stem cell technology that dramatically reduces IVF stimulation duration from 10 days to 2–3 days, making fertility treatment faster, cheaper, and less invasive.

## Company Overview

Gameto is revolutionizing in vitro fertilization by engineering ovarian granulosa cells from stem cells that can mature patient eggs in the lab, eliminating the lengthy and hormone-intensive stimulation protocols required by conventional IVF. The company's Fertilo technology co-incubates patient egg cells with Gameto's lab-grown granulosa cells, achieving maturation in 2–3 days versus the 10+ days of hormone injections that characterize standard IVF stimulation.

Founded in 2021 by Harvard reproductive biologists, Gameto has demonstrated clinical proof-of-concept with its granulosa cell co-culture system and is advancing toward broader clinical adoption. The $70M Series B will fund pivotal trial design and manufacturing scale-up for commercial launch. The technology could make IVF accessible to patients who cannot tolerate hormone stimulation due to polycystic ovary syndrome (PCOS) or cancer treatment history.

The global IVF market exceeds $25B annually with 8 million cycles performed worldwide, yet completion rates remain below 40% due to egg quality issues. Gameto's platform directly addresses egg maturation quality through the cell biology rather than through hormonal manipulation, potentially improving both success rates and patient experience simultaneously.

## Frequently Asked Questions

### How does Gameto's technology work?
Gameto engineers ovarian granulosa cells from stem cells that co-incubate with a patient's eggs in the lab, maturing them in 2–3 days without the 10+ days of hormone injections required by conventional IVF stimulation.

### Who benefits most from Gameto's approach?
Patients with PCOS, cancer treatment history, or poor response to hormone stimulation who cannot safely undergo conventional IVF benefit most from Gameto's hormone-free egg maturation approach.

### What is Gameto's market opportunity?
The global IVF market exceeds $25B annually with 8 million cycles performed. Gameto targets improvements in both access (by removing hormone barriers) and outcomes (through better egg maturation biology).

### What is Gameto's Fertilo product?
Fertilo is Gameto's first clinical product — a cell therapy that matures human eggs (oocytes) faster in vitro by co-culturing them with Gameto's engineered ovarian support cells. Conventional IVF requires 10-14 days of hormone stimulation to mature eggs in the body; Fertilo aims to reduce or eliminate this hormone stimulation phase by completing maturation in the lab, potentially enabling IVF with natural cycle egg retrieval.

### How much has Gameto raised and who are its investors?
Gameto has raised over $40 million from investors including Lux Capital, a16z Bio, and others. The company is a graduate of Y Combinator and has attracted investors who see the women's reproductive health market as significantly underinvested relative to its clinical burden. Gameto's scientific founders come from the Wyss Institute at Harvard and have published peer-reviewed research on ovarian biology underpinning the technology.

### What is the clinical development status of Gameto's technology?
Gameto has completed preclinical validation and entered early clinical testing of Fertilo, with collaborating IVF clinics running studies on in vitro maturation outcomes using Gameto's engineered support cells. The company is building the clinical evidence base required for FDA De Novo classification as a medical device or biologics license application, depending on regulatory pathway determination.

### Why does reducing IVF hormone stimulation matter clinically?
IVF hormone stimulation protocols involve daily injections for 10-14 days, cause significant side effects (bloating, mood changes, ovarian hyperstimulation syndrome in ~1-2% of patients which can be life-threatening), and cost $2,000-5,000 in medications alone per cycle. A hormone-free or hormone-reduced IVF protocol would improve patient experience, expand access (lower cost), and enable IVF for patients who cannot safely undergo ovarian stimulation due to hormone-sensitive cancers.

### What is the total addressable market for Gameto's technology?
Approximately 2 million IVF cycles are performed globally annually, with the market expected to grow at 8-10% CAGR as fertility rates decline and social egg freezing increases. At a conservative per-cycle pricing of $1,000-2,000 for Fertilo co-culture media and cells, the addressable market is $2-4 billion annually. Success would also open applications in egg freezing for fertility preservation, donor egg programs, and potentially oncofertility (egg preservation before cancer treatment).

## Tags

healthtech, technology, startup, b2b, global

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*Data from geo.sig.ai Brand Intelligence Database. Updated 2026-04-14.*