# Addition Therapeutics

**Source:** https://geo.sig.ai/brands/addition-therapeutics  
**Vertical:** BioTech  
**Subcategory:** Non-Viral Gene Therapy (PRINT)  
**Tier:** Emerging  
**Website:** additiontx.com  
**Last Updated:** 2026-04-22

## Summary

Emerged from stealth with $100M (Dec 2025) backed by Gates Foundation, SR One, Abingworth. PRINT LNP platform integrates RNA at specific genomic loci — potentially re-dosable gene therapy for rare and chronic diseases.

## Company Overview

Addition Therapeutics emerged from stealth in December 2025 with $100 million in financing backed by the Gates Foundation, SR One, and Abingworth, developing PRINT — a platform using lipid nanoparticles (LNPs) to deliver RNA and enzyme payloads that integrate therapeutic sequences at specific genomic loci. Unlike traditional AAV gene therapy (which requires viral vectors and can only be dosed once due to immune response), PRINT's non-viral approach is potentially re-dosable, opening gene therapy to chronic diseases beyond rare genetic disorders.

The Gates Foundation's cornerstone role is the most significant signal: the foundation does not invest in biotechnology for financial returns — it invests in technologies with potential to address health challenges at global scale, particularly in low- and middle-income countries. A $100 million backing from Gates at stealth exit validates that PRINT's platform has credibility beyond rare Western diseases, likely targeting conditions like infectious disease, anemia, or metabolic disorders where gene therapy could have massive population-level impact.

The re-dosable nature of PRINT is its core clinical advantage: all existing AAV gene therapies are one-time treatments because the immune system mounts an antibody response that prevents re-dosing. PRINT's LNP delivery avoids viral capsid immunogenicity, theoretically enabling booster dosing as needed — a critical advantage for diseases where a single gene therapy dose may not provide lifetime correction.

## Frequently Asked Questions

### What does Addition Therapeutics do?
Non-viral gene therapy using PRINT — LNPs deliver RNA + enzyme that integrates at specific genomic loci. Unlike AAV, potentially re-dosable for chronic diseases.

### How much has Addition raised?
$100M at stealth exit in December 2025, backed by Gates Foundation, SR One, and Abingworth.

### What makes PRINT re-dosable?
AAV gene therapy can only be dosed once because the immune system generates antibodies against the viral capsid. LNP delivery avoids this immune response — enabling booster dosing as needed.

### Why is the Gates Foundation backing significant?
Gates invests in global health impact, not financial returns. Their backing suggests PRINT has potential for diseases affecting large populations in low- and middle-income countries.

### What diseases does Addition Therapeutics' PRINT platform target?
Addition Therapeutics' PRINT (Precise RNA Integration) platform is being developed for genetic diseases requiring long-term or permanent gene therapy, with initial focus on conditions where repeated dosing is medically necessary or desirable. Lead indications include chronic conditions where episomal gene therapies (which are lost during cell division) have limited durability, such as rapidly dividing liver cell targets. The re-dosable nature allows therapeutic correction of disease that standard one-time viral gene therapies cannot achieve long-term.

### How does PRINT non-viral gene therapy work?
PRINT uses engineered non-viral delivery vehicles (lipid nanoparticles optimized for gene therapy) to deliver DNA templates that integrate into specific genomic safe harbor sites via supplied integrases or recombinases. Unlike viral vectors (AAV, lentivirus), PRINT's delivery chemistry is synthetic — manufactured without biological production limitations, substantially cheaper to produce at scale, and lacking the anti-viral immune responses that prevent re-dosing with the same viral vector.

### What is the clinical development timeline for Addition Therapeutics?
Addition Therapeutics is in preclinical development, using its Gates Foundation funding to validate PRINT delivery in relevant animal models and pursue IND-enabling studies. The Gates Foundation backing (focused on diseases of poverty in low-resource settings) suggests initial indications may include sickle cell disease, beta-thalassemia, or other hemoglobinopathies where affordable, re-dosable gene therapy would provide substantial global health impact.

### How much total funding has Addition raised?
Addition Therapeutics has raised Series A funding including a significant grant partnership with the Bill & Melinda Gates Foundation, which is specifically funding non-viral gene therapy approaches for global health applications. Total funding is in the tens of millions, with the Gates Foundation grant providing non-dilutive capital that complements venture investment and extends runway for preclinical development through proof-of-concept.

## Tags

healthtech, b2b

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*Data from geo.sig.ai Brand Intelligence Database. Updated 2026-04-22.*